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QDSTTM, rapid tuberculosis Drug Susceptibility Testing

QDST is a rapid, phenotypic drug susceptibility testing system for tuberculosis. The system provides susceptibility test results for 15 drugs, including first and second line agents, in just a week, which can allow laboratories to shorten turnaround time by 3 to 5 weeks compared to the conventional test methods.

  • TB susceptibility results in 7 days
  • Random access with 120 sample capacity
  • Incubation for TB culture
  • Fully automated optical imaging to monitor bacterial growth
  • Algorithm based image analysis technology
  • S/R results based on critical concentration

QuantaMatrix's microbial diagnostics solutions are the first to be developed in Korea and have received the highest honors including the New Excellent Technology (NET) certification and new medical technology certification.

TB drug susceptibility test results in a week

QDST provides results of drug susceptibility test for tuberculosis in just 7 days. Compared to conventional test methods, which takes 4 to 6 weeks, QDST dramatically reduces time to results.

* DST: Drug Susceptibility Test for Mycobacterium tuberculosis
QDST with liquid culture

  • Liquid Culture

  • QDST
1 week DST
QDST with solid culture

  • Solid Culture

  • QDST
1 week DST SAVE 5 WEEKS

Conventional DST with Solid Culture

  • Solid Culture

  • DST
6 week DST
0 1 2 3 4 5 6 7 8 9 10
weeks

Treatment Decision Support

QMAC-DSTTM PLUS panel includes LNZ and Cs to help clinicians prescribe optimal treatment for patients with drug-resistance TB. Meanwhile, multi-concentration wells are available for INH, RIF, EMB, and Cs. High- and low-level resistance concentrations are provided in addition to the critical concentration, promoting better informed treatment decisions.

Benefits

  • 1 week

    Turn-around Time
    for TB DST

  • 3 level safety system

    Protect Users

  • 120 samples

    with Random Access

QDST Kit

QMAC-DSTTM PLUS kit offers a QMAC-DSTTM PLUS Panel together with panel sealer. The panel accommodates 4 primary and 11 secondary anti-TB drugs with multiple concentrations. In addition to the agarose that immobilizes the TB bacteria, the panel cover and panel sealer serve to ensure user safety.

  • 1st line drugs
    Drug Concentration (μg/mL)
    Isoniazid (INH) 0.1    0.4* 
    Rifampicin (RIF) 0.75*1.5   
    Ethambutol (EMB) 2.5*    5.0 
    Rifabutin (Rfb) 1.25 

    * Reference concentration. Others are critical concentration.

  • 2nd line drugs
    Drug Concentration (μg/mL)
    Moxifloxacin (Mfx) 0.5    
    Levofloxacin (Lfx) 0.75 
    Ofloxacin (Ofx) 2.0    
    Linezolid (LNZ) 1.0    
    Cycloserine (Cs) 8.0* 16.0    
    Amikacin (Am) 2.0    
    Capreomycin (Cm) 2.5    
    Kanamycin (Km) 2.5    
    Streptomycin (S) 1.0    
    Para-aminosalicylic acid (PAS) 4.0    
    Prothionamide (Pto) 2.5 

3-level safety system

The safety of the user is of utmost importance because tuberculosis is carried in airborne particles. QMAC-DSTTM PLUS Panel has a total of three levels of safety as shown below to prevent samples from leaking during the testing process.

  • Level 1

    Immobilize TB bacteria in the agarose layer

  • Level 2

    Seal the panel with panel sealer
    to prevent leakage of sample

  • Level 3

    Lock the panel with the panel cover

Optional Accessories for QMAC-DSTTM PLUS kit

  • QM 7H9 Broth w/o OADC

    Mix QM 7H9 Broth with OADC

    Load liquid media after Inoculation of TB bacteria

  • QM Agarose

    Fix TB bacteria

  • QM Bead Tube

    Pretreat TB bacteria

QDST Workflow

  • STEP 1

    Prepare mixture of cultured tuberculosis bacteria and agarose for immobilization.

  • STEP 2

    Dispense mixture and media on QDST panel ccontaining preloaded and dried antibiotics.

  • STEP 3

    Prepared panel is automatically loaded into 120 plate loaders in QDST.



  • STEP 4

    Observation of bacterial growth and resistance to the drug within 7days through fully automated optical imaging.

  • STEP 5

    Susceptibility results are reporting using proprietary algorithm and database based on critical concentration.

User-friendly interface

QDSTTM software utilizes a proprietary algorithm and database set to perform advanced drug susceptibility testing. Fully automated time-lapse imaging allows for highly precise measurement and calculation of micro-colony growth.

  • Easy and simple to use

    12 inch touch screen promotes convenience

  • Image Display

    Cell growth images are illustrated alongside the control image for side-by-side comparison

  • Proprietary Algorithm

    S/R determination is obtained through proprietary algorithm